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Metastasis, development of resistance to treatments, and tumor relapse are fundamental reasons for most cancer patient-related mortality. In my laboratory, we aim to understand the fundamental biology of cancer progression and, in particular, to comprehend how tumors become highly aggressive, develop resistance to therapies, and eventually become metastatic.
Our research, along with others, has demonstrated that the aberrant activation of a latent embryonic program—known as the epithelial-mesenchymal transition (EMT), makes the cancer cells migratory, invasive, and metastatic ( Yang and Mani et al., Cell 2004 ; Mani & Yang et al., PNAS 2007 ).